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学位論文 |
学位
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片山, 千佳
概要:
Thesis or Dissertation<br />学位記番号：医博甲1858
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| 2.
学位論文 |
学位
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金山, 雄樹
概要:
Thesis or Dissertation<br />学位記番号：医博甲1839
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| 3.
学位論文 |
学位
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八木, 久子
概要:
Thesis or Dissertation<br />学位記番号：医博甲1799
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| 4.
学位論文 |
学位
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高橋, 研吾
概要:
Thesis or Dissertation<br />学位記番号：医博甲1587
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| 5.
論文 |
論文
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Iijima, Kotaro ; Yoshimoto, Masataka ; Horiguchi, Jun ; Oyama, Tetsunari ; Morishita, Yasuo ; Kasumi, Fujio ; Sakamoto, Goi
概要:
application/pdf<br />Journal Article<br />Background & Aims: The purpose of this study was to investigate the influence
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of pregnancy on breast\ncancer prognosis by analyzing clinical and pathological features of young patients with breast cancer in\nrelation to last birth. Method: A total of 622 young breast cancer patients under 35 years of age\nundergoing surgical treatment between 1960 and 1990 at Cancer Institute Hospital were included in this\nstudy. The patients were classified into four groups; group A patients who were diagnosed during\npregnancy or within one year after delivery, group B patients who were diagnosed from one to three years\nafter delivery, group C patients who were diagnosed three years or more after delivery, and group D\npatients who were nulliparous. All four groups were examined from the viewpoint of clinical and\npathological findings with regard to age, disease duration, first childbirth, clinical stage, histopathological\ntype, lymph node metastasis, and survival. Furthermore, nuclear grade and immunohistochemical\nstaining of both estrogen receptor (ER) and factor-VIII were examined in early-stage breast\ncancer patients. Result: The incidence of early-stage(0, I and II) breast cancer was significantly(p＜\n0.05) lower in group A (69％) than in groups C (88％) and D (85％). The incidence of nodal involvement\ndecreased from group A (61％), B (59％), C (51％) to D (43％) in that order. The incidence of\nnodal involvement in group D was significantly (p＜0.05) lower than that in groups A and B. The\npositive rate of estrogen receptor increased from group A (50％), B (56％) to C (72％) in that order. \nDisease-free survival was significantly (p＜0.05) more favorable in group D than in groups A and C. \nThe similar result was obtained in patients with clinically early-stage breast cancer. Conclusion:\nPatients who developed breast cancer during pregnancy or within less than one year postpartum have a\npoor prognosis among patients under 35 years old. Patients having no childbirth history generally have\na high risk factor of developing breast cancer, however, breast cancer patients without childbirth history\nunder 35 years old result in a favourable prognosis.
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| 6.
学位論文 |
学位
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佐藤, 正行
概要:
Thesis or Dissertation<br />学位記番号：医博甲1886
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