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Manduul, Enkhjargal ; Nakajima, Takahito ; Shibuya, Kei ; Shrestha, Suman ; Hirasawa, Hiromi ; Tsushima, Yoshito
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Journal Article<br />This study evaluated liver function using gadoxetic acid-enhanced magnetic resonance imaging (EOB-M
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RI) to improve assessment of patients with liver tumors compared to Child-Pugh classification (CPC). Materials and methods: The liver function of 59 patients was assessed to determine the indication for heavy ion therapy. Clinical and laboratory assessments, including 99mTc-GSA liver scintigraphy and indocyanine green retention index (ICGR15), were performed for liver function assessment. EOB-MRI was performed on T1W1 images both before and after Gd-EOB-DTPA administration and hepatobiliary phase images were acquired 20-min post-injection. Liver parenchymal enhancement ratio (LER) was measured based on liver-to-spleen (L/Sp) ratios calculating the average liver intensity divided by spleen intensity. Results: The mean LER values on MRI were 138.2±12.8 (133.9-142.5), 115.7±11.6 (110.0-121.5), and 93.2±15.8 (73.6-112.9) in CPC-A, -B and -C, respectively. From the correlation between the LER on MRI and ICGR15 and parameters of 99mTc-GSA liver scintigraphy, LER on MRI was highly significantly correlated with ICGR15 (r=-0.67; p<0.0001). Discussion: This study demonstrated that LER values on EOB-MRI could classify liver function and had high correlation with CPC and ICGR15.
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Kanzaki, Takao ; Tran, Vu Quynh Vy ; Higuchi, Tetsuya ; Nakajima, Takahito ; Achmad, Arifudin ; Takahashi, Yasuyuki ; Taketomi-Takahashi, Ayako ; Suto, Takayuki ; Tsushima, Yoshito
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Journal Article<br />Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT)
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or dopamine transporter (DAT) SPECT scan quantitatively depicts striatum dopamine transporter density. The specific binding ratio (SBR) is important for Parkinson's disease (PD) diagnosis. Correction techniques may improve 123I-FP-CIT image quality, but they are currently not standardized. We aim to determine attenuation correction (AC) and scatter correction (SC) influence on 123I-FP-CIT quantitative analysis. Methods: We preformed SPECT imaging on a striatal phantom representing striatum-to-background ratios ranging from 10:1 to 1:1. We used the Chang method for AC and triple energy window for SC. Commercially available software semi-automatically calculated SBR. We performed correlation analysis between SBR and the actual concentration ratio in four groups: no correction (NC), SC, AC, and combined correction (CC), paying particular attention to SBR values below the clinical cut-off (4.5). We applied the same imaging conditions, reconstruction, and corrections on 49 human 123I-FP-CIT SPECT studies. Asymmetric index values (AI) were also analyzed. Receiver operating characteristic (ROC) analysis provided AI diagnostic cut-off values in PD patients. PD patient population whose AI values were above these cut-off value were subject to a correlation study to confirm the association between their clinical symptoms and 123I-FP-CIT SPECT. Results: Phantom study. AC or CC increased SBR 123I-FP-CIT SPECT, making them very close to the standard ratios (AC: y=1.19x - 0.7; R2=0.98; CC: y=1.4x - 1.2; R2=0.98), while NC and SC underestimated SBR at lower values (1 to 4). Clinical study. There was no difference in SBR between NC and SC, while AC and CC produced significantly higher SBR than NC (p<0.0001). Only SC affected AI values (p<0.05). The association between clinical symptoms and 123I-FP-CIT imaging results were maintained only when either NC (n=12, p<0.05) or CC (n=14, p<0.05) was applied. Conclusions: AC increased SBR more than other corrections, while SC increased AI value more than other corrections. The association between clinical symptom and SPECT findings were maintained when either NC or CC was applied. These correction methods should be carefully selected for 123I-FP-CIT SPECT brain imaging.
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Khairinisa, Miski Aghnia ; BiomedSc, M. ; Takatsuru, Yusuke ; Amano, Izuki ; Khongorzul, Erdene ; Nakajima, Takahito ; Kameo, Satomi ; Koyama, Hiroshi ; Tsushima, Yoshito ; Koibuchi, Noriyuki
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Tomonaga, Hiroyasu ; Nakajima, Takahito ; Arisak, Yukiko ; Tokue, Azusa ; Higuch, Tetsuya ; Tsushima, Yoshito
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Journal Article<br />Background&Aims:This study aimed to evaluate the diagnostic performance and features of a computer-
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assisteddiagnostic system.BONENAVI versions 1(BN1)and 2(BN2)were used to detect lesions on bone scintigraphy.Methods:Bone scintigraphy of 33 prostate cancer and 27 breast cancer patients with bone metastases was evaluated.Spots detected and analyzed by BN1 and BN2 were compared with those of manual analyses by nuclear medicinephysicians.Results:The sensitivity of BN1 and BN2 was 99.2％ and 97.0％ for prostate cancer and 96.8％ and 95.0％ for breastcancer,respectively.The specificity was 64.7％ and 68.0％ for prostate cancer and 65.3％ and 75.8％ for breastcancer,respectively.Positive predictive values tended to be higher for BN2,and negative predictive values tendedto be higher for BN1. BN2 showed fewer false positive spots. BN2 was superior to BN1 for detection ofphysiological uptake in the head and pelvis in breast cancer and in the cervical/lumbar spine in both breast andprostate cancer.Conclusions:BN2 showed better diagnostic performance than BN1.Understanding the characteristics of lesiondetection using each version of BONENAVI may be useful when evaluating new lesions on bone scintigraphy.
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Kartamihardja, A.Adhipatria P. ; Nakajima, Takahito ; Kameo, Satomi ; Koyama, Hiroshi ; Tsushima, Yoshito
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An, Binh Dang ; Shimada, Hirotaka ; Kanzaki, Takao ; Achmad, Arifudin ; Nakajima, Takahito ; Higuchi, Tetsuya ; Tsushima, Yoshito
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Thu, Huong Nguyen ; Hanaoka, Hirofumi ; Nakajima, Takahito ; Tsushima, Yoshito
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Zhang, Xieyi ; Kim, Mai ; Yamaguchi, Aiko ; Nakajima, Takahito ; Tsushima, Yoshito
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Duc, Binh Duong ; Higuchi, Tetsuya ; Achmad, Arifudin ; Nakajima, Takahito ; Teketomi-Takahashi, Ayako ; Tsushima, Yoshito
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