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論文
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Yoshida, Kensuke ; Kimura, Takao ; Shimizu, Tomo ; Sato, Koichi ; Aoki, Tomoyuki ; Sumino, Hiroyuki ; Tsunekawa, Katsuhiko ; Mitazaki, Osamu ; Fukamachi, Isamu ; Nakajima, Katsuyuki ; Okajima, Fumikazu ; Murakami, Masami
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Sumino, Hiroyuki ; Ichikawa, Shuichi ; Kasama, Shu ; Ichikawa, Akiko ; Araki, Yoshihiro ; Kanai, Hiroyoshi ; Itoh, Toshio ; Iwasaki, Toshiya ; Sawada, Yoshie ; Takahashi, Takashi ; Kumakura, Hisao ; Takayama, Yoshiaki ; Minami, Kazutomo ; Kurabayashi, Masahiko ; Murakami, Masami
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Journal Article
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論文
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Yoshida, Kensuke ; Kimura, Takao ; Shimizu, Tomo ; Sato, Koichi ; Aoki, Tomoyuki ; Sumino, Hiroyuki ; Tsunekawa, Katsuhiko ; Miyazaki, Osamu ; Fukamachi, Isamu ; Nakajima, Katsuyuki ; Okajima, Fumikazu ; Murakami, Masami
概要:
Journal Article<br />Background:Apolipoprotein M (ApoM) is bound to high-density lipoprotein (HDL) in plasma, and HDL ha
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santicoagulation effects. However, the association between ApoM and biomarkers of coagulation was unclear.Therefore, we investigated relationships between ApoM and biomarkers of coagulation.Methods: Serum samples from 233 Japanese participants including with diabetes mellitus, hypertension,dyslipidemia, or healthy controls were analyzed. Serum ApoM levels were measured using Enzyme-LinkedImmuno-Sorbent Assay(ELISA).Results:Analysis of all 233 participants showed that ApoM levels were positively correlated with age (r＝0.284,p＜0.001), total cholesterol (TC;r＝0.477, p＜0.001), HDL-cholesterol (HDL-C;r＝0.234, p＜0.001) and lowdensitylipoprotein cholesterol (LDL-C;r＝0.331, p＜0.001). Higher ApoM levels were correlated with shorteractivated partial thromboplastin time(APTT;r＝－0.226,p＝0.001) and prothrombin time(PT,％;r＝0.326,p＜0.001). Separate analysis of the 115 healthy controls showed that ApoM levels were positively correlated with age,TC, HDL-C and LDL-C, and higher ApoM levels were correlated with shorter PT.Conclusion:Serum levels of ApoM may influence biomarkers of coagulation.
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