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中里, 享美
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Journal Article
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中里, 享美 ; 中嶋, 克行 ; 鈴木, 慶二 ; 時田, 佳治 ; 関根, 宏美 ; 菊地, 弘記 ; 長嶺, 竹明
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application/pdf<br />Journal Article
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中里, 享美 ; 鈴木, 慶二 ; 中嶋, 克行
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application/pdf<br />Departmental Bulletin Paper<br />カドミウム投与によるマウス諸臓器のメタロチオネイン(MT)の発現について,免疫染色,in situ hybridization法,N
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orthern blot hybridization法を用いて検討した。免疫染色では,無処置マウス諸臓器はMT軽度陽性または陽性を示し,Cd投与後に染色性の増強を認めたが,特に腎尿細管上皮で染色性の増強が強かった。また,MT-I mRNAは無処置マウス肝,腎で多量認められ,Cd投与後の増加は緩やかであったが,MT-II mRNAは無処置マウス肝,腎に少量しか認められず,Cd投与後の増加は急激であった。これらの結果より,Cd投与に対するMTの解毒作用は,最初にMT-Iが弱く,ついでMT-IIが強く関与して行うものと考えられる。
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中里, 享美 ; 原, 文子 ; 原田, 和彦 ; 押谷, 節子 ; 青木, 万里子 ; 福村, 幸仁
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application/pdf<br />Departmental Bulletin Paper<br />We examined the plasma protein fraction and the plasma glycoprotei
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n fraction in patients with diabetes mellitus, and analyzed the difference of the results from those of normal people and the relation between the results and the complications of diabetes mellitus. In plasma protein fraction, α_2, β_1 and β_2 grobulin fractions of the patients were higfer than those of normal people. In plasma glycoproteinfraction, α_1, β_1 and β_2 grobulin fractions of the patients were higfer than those of normal people. And then, the examined plasma glycoprotein fractions were classified into five groups by the differences of the figure of fraction, and the results of such classification suggested that the each group had significant relation to the complications of diabetes mellitus.
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中里, 享美 ; 小河原, はつ江 ; 原, 文子 ; 土屋, 純 ; 押谷, 節子 ; 福村, 幸仁
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application/pdf<br />Departmental Bulletin Paper<br />In old people, normal reference range of several clinical chemistr
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y tests change with aging. We studied the difference of the results in serum protein fraction and several clinical chemistry tests between normal adults and old people, and between the healthy old people and bedridden old people. As a result, there was increase of albumin and decrease of globulin in serum protein fraction of the old people compared with that of the normal adults. The results of total protein, cholinesterase, creatinine, and β2-microglobulin in clinical chemistry tests made a significant difference between the old people and the normal adults. The results of creatinephosphokinase, total cholesterol, and zinc sulfate turbidity test made a significant difference between the healthy old people and the bedridden old people. And then, a serum sample having the fraction seemed to be M protein was found serum protein fraction. We analysed it by several electrophoretic analysis, and found that the result was differed from that of other samples.
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小河原, はつ江 ; 中里, 享美 ; 飯田, 義裕 ; 城下, 尚 ; 土屋, 純
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application/pdf<br />Departmental Bulletin Paper<br />A smear specimen is usually dried by blowing cool air. But we are not exactly sure why we use cool air for drying smears. We studied the effects of drying temperature upon the
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morphological change of blood cells in both the Romanowsky stain (Wright method) and the cytochemical peroxidase reaction. In the Wright stain, the rate of hemolysed red blood cells increased in proportion to the rise in the drying temperature of the smear. However, the morphological state of the white blood cells remained unchanged. In the cytochemical peroxidase reaction, myeloperoxidase (MPO) positive granules of neutrophil leukocytes and monocytes decreased in proportion to the rise in the drying temperature of the smear. And then the neutrophil MPO score significantly decreased depending on the drying temperature.
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小河原, はつ江 ; 柴川, 直子 ; 村上, 博和 ; 土屋, 純 ; 中里, 享美
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application/pdf<br />Departmental Bulletin Paper
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