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論文
論文
1. Systematic immunohistochemical profiling of 378 brain tumors with 37 antibodies using tissue microarray technology
Ikota, Hayato ; Kinjo, Sawako ; Yokoo, Hideaki ; Nakazato, Yoichi
出版情報: Acta Neuropathologica.  111  pp.475-482,  2006-05.  Springer Science + Business Media
概要: application/pdf<br />Journal Article<br />We performed a systematic immunohistochemical study on 378 brain tumors using 37 antibodies and tissue microarray (TMA) technology. The aim of this study was to find new diagnostic … biomarkers using antibodies established in our laboratory. Our TMA consisted of a grid of 1.5-mm cores that were extracted from individual donor blocks. Staining for each antibody was scored using a three-point system. We used hierarchical clustering analysis to interpret these data, which resulted in separation of all the brain tumors into seven groups. Although there were some exceptions, cases with the same histological diagnosis were generally grouped together. We then carried out statistical analyses to find the most useful antibodies for grouping of brain tumors. Ten antibodies [glial fibrillary acidic protein (GFAP), Olig2, vimentin, epithelial membrane antigen (EMA), cytokeratin (AE1/AE3), alpha-internexin, nestin, pinealocytes PP5, aquaporin-4 (AQP4) M13d and AQP4M13e] discriminated between astrocytomas and oligodendroglial tumors. Six antibodies [EMA, AE1/AE3, TUJ1, nestin, neurofilament protein-MH (NF-MH) and perivascular cells GP-1] showed significant differences between high-grade and low-grade gliomas. Our data have revealed new antibodies with potential diagnostic utility (Olig2, PP5, GP-1) and demonstrate that TMA technology is highly useful for evaluating newly established antibodies in brain-tumor research.<br />The original publication is available at www.springerlink.com 続きを見る
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論文
論文
2. Hypocalcemic Myopathy in Hypoparathyroidism : Immunohistochemical Demonstration of Myoglobin Leakage
Yamaguchi, Haruyasu ; Okamoto, Koichi ; Shooji, Mikio ; Morimatsu, Mitsunori ; Hirai, Shunsaku
出版情報: 群馬大学医療技術短期大学部紀要.  7  pp.223-230,  1987-02-20.  群馬大学医療技術短期大学部
概要: application/pdf<br />Departmental Bulletin Paper<br />A woman with idiopathic hypoparathyroidism presented with proximal limb weakness, easy fatigability, hoarseness and elevated serum creatine kinase associated with hypocalcemia. As … these findings disappeared after normalization of the serum calcium level with treatment, the diagnosis of hypocalcemic myopathy was established. Muscle biopsy showed type 2 fiber atrophy and. Immunohistochemical investigation revealed myoglobin loss from some muscle fibers, suggesting that hypocalcemia itself may produce myopathy associated with myoglobin loss without structural changes. 続きを見る