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Kumasaka, Yuka ; Aoki, Jun ; Amanuma, Makoto ; Itoh, Masahiro ; Oota, Katsuto ; Kumasaka, Soma ; Tsushima, Yoshito
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Journal Article<br />北関東医学会The KITAKANTO Medical Journal優秀論文賞
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Purev, Odonchimeg ; Enkhjargal, Manduul ; Ogawa, Shota ; Purevsukh, Tugsjargal ; Dagvasumberel, Munkhbaatar ; Oidov, Batgerel ; Taketomi-Takahashi, Ayako ; Tsushima, Yoshito ; Iwase, Akira ; Shinozaki, Hiromitsu
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3. Computed Tomography Characteristics of Ruptured Corpus Luteum: Does Prior Coitus Modify Findings?
Kumasaka, Yuka ; Aoki, Jun ; Amanuma, Makoto ; Itoh, Masahiro ; Oota, Katsuto ; Kumasaka, Soma ; Tsushima, Yoshito
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Journal Article<br />Background & Aims: To determine the effect of prior coitus on CT findings of ruptured corpus luteum
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. Methods: The subjects were female patients complaining of acute lower abdominal pain, who underwent CT examination. Patients meeting the following criteria were diagnosed with ruptured corpus luteum: 1) an adnexal cystic mass with thick wall, 2) high density ascites (≥20 Hounsfield Units [H.U.]), 3) no CT evidence of acute abdominal diseases, 4) no pregnancy, 5) no prior history of chronic lower abdominal pain, and 6) relief of pain within two weeks. These patients were classified into two groups: with and without coitus within three days before the onset. Then, CT findings were evaluated. Results: A total of 18 patients fulfilled the criteria. Patients with prior coitus (n＝9) showed a larger maximum diameter of the adnexal cyst (38.8 vs 23.5 mm, p＝0.005), higher attenuation of ascites (41 vs 25 H.U., p＝0.017), and a larger amount of ascites (pelvis-limited or beyond pelvis) (p＝0.015), compared to the others (n＝9). Conclusions: Prior coitus affected CT findings such as a larger amount of ascites with higher attenuation.
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Yudistiro, Ryan ; Heryanto, Yusri Dwi ; Kodaira, Sayaka ; Higuchi, Tetsuya ; Arisaka, Yukiko ; Tokue, Azusa ; Taketomi-Takahashi, Ayako ; Tsukamoto, Norifumi ; Yokohama, Akihiko ; Handa, Hiroshi ; Koiso, Hiromi ; Ishizaki, Takuma ; Tsushima, Yoshito
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Manduul, Enkhjargal ; Nakajima, Takahito ; Shibuya, Kei ; Shrestha, Suman ; Hirasawa, Hiromi ; Tsushima, Yoshito
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Journal Article<br />This study evaluated liver function using gadoxetic acid-enhanced magnetic resonance imaging (EOB-M
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RI) to improve assessment of patients with liver tumors compared to Child-Pugh classification (CPC). Materials and methods: The liver function of 59 patients was assessed to determine the indication for heavy ion therapy. Clinical and laboratory assessments, including 99mTc-GSA liver scintigraphy and indocyanine green retention index (ICGR15), were performed for liver function assessment. EOB-MRI was performed on T1W1 images both before and after Gd-EOB-DTPA administration and hepatobiliary phase images were acquired 20-min post-injection. Liver parenchymal enhancement ratio (LER) was measured based on liver-to-spleen (L/Sp) ratios calculating the average liver intensity divided by spleen intensity. Results: The mean LER values on MRI were 138.2±12.8 (133.9-142.5), 115.7±11.6 (110.0-121.5), and 93.2±15.8 (73.6-112.9) in CPC-A, -B and -C, respectively. From the correlation between the LER on MRI and ICGR15 and parameters of 99mTc-GSA liver scintigraphy, LER on MRI was highly significantly correlated with ICGR15 (r=-0.67; p<0.0001). Discussion: This study demonstrated that LER values on EOB-MRI could classify liver function and had high correlation with CPC and ICGR15.
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Kanzaki, Takao ; Tran, Vu Quynh Vy ; Higuchi, Tetsuya ; Nakajima, Takahito ; Achmad, Arifudin ; Takahashi, Yasuyuki ; Taketomi-Takahashi, Ayako ; Suto, Takayuki ; Tsushima, Yoshito
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Journal Article<br />Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT)
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or dopamine transporter (DAT) SPECT scan quantitatively depicts striatum dopamine transporter density. The specific binding ratio (SBR) is important for Parkinson's disease (PD) diagnosis. Correction techniques may improve 123I-FP-CIT image quality, but they are currently not standardized. We aim to determine attenuation correction (AC) and scatter correction (SC) influence on 123I-FP-CIT quantitative analysis. Methods: We preformed SPECT imaging on a striatal phantom representing striatum-to-background ratios ranging from 10:1 to 1:1. We used the Chang method for AC and triple energy window for SC. Commercially available software semi-automatically calculated SBR. We performed correlation analysis between SBR and the actual concentration ratio in four groups: no correction (NC), SC, AC, and combined correction (CC), paying particular attention to SBR values below the clinical cut-off (4.5). We applied the same imaging conditions, reconstruction, and corrections on 49 human 123I-FP-CIT SPECT studies. Asymmetric index values (AI) were also analyzed. Receiver operating characteristic (ROC) analysis provided AI diagnostic cut-off values in PD patients. PD patient population whose AI values were above these cut-off value were subject to a correlation study to confirm the association between their clinical symptoms and 123I-FP-CIT SPECT. Results: Phantom study. AC or CC increased SBR 123I-FP-CIT SPECT, making them very close to the standard ratios (AC: y=1.19x - 0.7; R2=0.98; CC: y=1.4x - 1.2; R2=0.98), while NC and SC underestimated SBR at lower values (1 to 4). Clinical study. There was no difference in SBR between NC and SC, while AC and CC produced significantly higher SBR than NC (p<0.0001). Only SC affected AI values (p<0.05). The association between clinical symptoms and 123I-FP-CIT imaging results were maintained only when either NC (n=12, p<0.05) or CC (n=14, p<0.05) was applied. Conclusions: AC increased SBR more than other corrections, while SC increased AI value more than other corrections. The association between clinical symptom and SPECT findings were maintained when either NC or CC was applied. These correction methods should be carefully selected for 123I-FP-CIT SPECT brain imaging.
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Khairinisa, Miski Aghnia ; BiomedSc, M. ; Takatsuru, Yusuke ; Amano, Izuki ; Khongorzul, Erdene ; Nakajima, Takahito ; Kameo, Satomi ; Koyama, Hiroshi ; Tsushima, Yoshito ; Koibuchi, Noriyuki
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Tomonaga, Hiroyasu ; Nakajima, Takahito ; Arisak, Yukiko ; Tokue, Azusa ; Higuch, Tetsuya ; Tsushima, Yoshito
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Journal Article<br />Background&Aims:This study aimed to evaluate the diagnostic performance and features of a computer-
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assisteddiagnostic system.BONENAVI versions 1(BN1)and 2(BN2)were used to detect lesions on bone scintigraphy.Methods:Bone scintigraphy of 33 prostate cancer and 27 breast cancer patients with bone metastases was evaluated.Spots detected and analyzed by BN1 and BN2 were compared with those of manual analyses by nuclear medicinephysicians.Results:The sensitivity of BN1 and BN2 was 99.2％ and 97.0％ for prostate cancer and 96.8％ and 95.0％ for breastcancer,respectively.The specificity was 64.7％ and 68.0％ for prostate cancer and 65.3％ and 75.8％ for breastcancer,respectively.Positive predictive values tended to be higher for BN2,and negative predictive values tendedto be higher for BN1. BN2 showed fewer false positive spots. BN2 was superior to BN1 for detection ofphysiological uptake in the head and pelvis in breast cancer and in the cervical/lumbar spine in both breast andprostate cancer.Conclusions:BN2 showed better diagnostic performance than BN1.Understanding the characteristics of lesiondetection using each version of BONENAVI may be useful when evaluating new lesions on bone scintigraphy.
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Yudistiro, Ryan ; Kosuda, Shigeru ; Higuchi, Tetsuya ; Taketomi-Takahashi, Ayako ; Tsushima, Yoshito
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Shresth, Suman ; Iso, Tatsuya ; Hanaoka, Hirofumi ; Sunaga, Hiroaki ; Yamaguchi, Aiko ; Tsushima, Yoshito ; Kurabayash, Masahiko
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Kartamihardj, A.Adhipatria P. ; Hanaoka, Hirofumi ; Kameo, Satomi ; Koyama, Hiroshi ; Tsushima, Yoshito
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Kartamihardja, A.Adhipatria P. ; Nakajima, Takahito ; Kameo, Satomi ; Koyama, Hiroshi ; Tsushima, Yoshito
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Thu, Huong Nguyen ; Hanaoka, Hirofumi ; Nakajima, Takahito ; Tsushima, Yoshito
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Yudistiro, Ryan ; Takahashi, Ayako ; Tsushima, Yoshito
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Zhang, Xieyi ; Kim, Mai ; Yamaguchi, Aiko ; Nakajima, Takahito ; Tsushima, Yoshito
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Duc, Binh Duong ; Higuchi, Tetsuya ; Achmad, Arifudin ; Nakajima, Takahito ; Teketomi-Takahashi, Ayako ; Tsushima, Yoshito
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Murakami, Tohru ; Tajika, Yuki ; Ueno, Hitoshi ; Awata, Sachiko ; Hirasawa, Satoshi ; Sugimoto, Maki ; Kominato, Yoshihiko ; Tsushima, Yoshito ; Endo, Keigo ; Yorifuji, Hiroshi
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Journal Article<br />It is essential to learn human anatomy in 3D for advanced medicine. We designed such\nan education
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system by integrating anatomy dissection with diagnostic CT radiology.\nCadavers were scanned by CT, and students consulted the postmortem CT images while\ndissecting the cadaver to gain a better understanding of 3D human anatomy and\ndiagnostic radiology. Students used handheld DICOM viewers at the bench-side (OsiriX\non iPod touch). Students had lectures and workshops on diagnostic radiology, and study\nassignments where they discussed findings in anatomy labs in comparison with CT\nradiology. This teaching method for gross anatomy was used from 2009, and yielded\npositive students’ perspectives, and significant improvements in radiology skills at\nclinical courses.<br />This is the pre-peer reviewed version of the\nfollowing article: Tohru Murakami, Yuki Tajika,\nHitoshi Ueno, Sachiko Awata, Satoshi\nHirasawa, Maki Sugimoto, Yoshihiko Kominato,\nYoshito Tsushima, Keigo Endo, and Hiroshi\nYorifuji. An integrated teaching method of gross\nanatomy and computed tomography radiology.\nAnat Sci Educ, 2014, which has been published\nin final form at http://onlinelibrary.wiley.com/\ndoi/10.1002/ase.1430/abstract.
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Shimada, Takehiro ; Amanuma, Makoto ; Takahashi, Ayako ; Tsushima, Yoshito
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Journal Article<br />Purpose: The aim of this study was to compare non-contrast 3T renal MRA with that of 1.5T unit.\nM
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ethods and M aterials : We performed renal MRA in twelve volunteers using a 1.5T and 3T unit. For\nrenal MRA, 3D SSFP sequence was used. For quantitative evaluation,ROI was set on the aorta,main\nstems of bilateral renal arteries, and IVC, measuring flow signal at each point. Signal intensity ratio\n(SIR) of renal artery relative to the parenchyma and IVC were calculated. For subjective analysis,two\nreaders evaluated visual quality. Results : SIR of the both renal artery on 3T MRA were significantly\nhigher than those on 1.5T (p＜0.01). On subjective analysis,the mean visualization score of renal main\nstem showed no statistically significant difference. However,the scores of the peripheral branches on 3T\nwas significantly higher than those of 1.5T bilaterally(p＜0.05). IVC showed significantly lower signal\nratio on 3T relative to that on 1.5T. Conclusion : 3T MRA showed superior demonstration of renal\narteries compared with 1.5T MRA. The intraparenchymal peripheral branches are especially well\ndemonstrated on 3T MRA. Decreased venous signal on 3T system contributed to the selective arterial\ndemonstration.
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Tsushima, Yoshito ; Endo, Keigo
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application/pdf<br />Journal Article<br />Aim: To find whether there were characteristic clinical or imaging findings in retroperitoneal fibrosis (RPF) confined in the pelvic cavity.\nMethods: Literature review was performed using
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MEDLINE with key words of [retroperitoneal fibrosis and pelvis] and [pelvic fibrosis].\nResults: In addition to our 68-year-old Japanese woman, 13 cases were found, in which computed tomography (CT) or magnetic resonance imaging (MRI) confirmed that the mass lesions were confined in the pelvic cavity. The pelvic RPF (age range, 29-69 y.o. ; seven male) showed variable symptoms and clinical presentation suggestive of gynecological, urological or colonic diseases. CT usually revealed an ill-defined well-enhanced mass lesion, which may be associated with fascial thickening. On MRI the pelvic masses showed low signal intensity on T1-weighted images and high or mixed signal on T2-weighted images. In nine of 14 patients the presacral or retrorectal spaces were involved, and the remaining patients had RPF around the bladder. In seven patients, imaging-guided needle biopsies were employed. Good prognoses were reported in all 11 patients, in which corticosteroid therapy were given.\nConclusion: Pelvic RPF may show different symptoms and clinical features from typical paraaortic RPF, but shows similar imaging findings. The imaging-guided biopsy is the choice for histopathological diagnosis.
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