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Factors Influencing Bone Healing after Extirpation with Endodontic Microsurgery-Microscopic Apicoectomy for Extensive Radicular Cysts

フォーマット:
論文
責任表示:
Ogawa, Masaru ; Yokoo, Satoshi ; Yamaguchi, Takahiro ; Suzuki, Keisuke ; Makiguchi, Takaya
言語:
英語
出版情報:
北関東医学会, 2019-11-01
著者名:
掲載情報:
The Kitakanto medical journal = 北関東医学
ISSN:
1343-2826  CiNii Research  JAIRO
巻:
69
通号:
4
開始ページ:
315
終了ページ:
324
バージョン:
VoR
概要:
Journal Article<br />Background & Aims: The purpose of this study is to identify the clinical and immunohistological factors that inhibit bone healing after extirpation of extensive radicular cysts and endodontic microsurgery-microscopic apicoectomy, and utilize these factors as predictors of treatment outcome. Methods: Endodontic microsurgery-microscopic apicoectomy was performed in 26 patients. Outcomes were evaluated based on clinical signs and radiographs. Expression levels of cytokines (IL-1β, TNF-α, RANKL) in the cyst epithelium and subepithelial connective tissue were also investigated. Results: The success rate was 88.5%. The radiological reduction rate was ≥75% in 16 patients (good bone healing) and <75% in 10 (poor bone healing). In clinical analysis, penetrating bone defects and the site (maxilla) showed significant differences between the two groups (P<0.05). In immunohistochemical analysis, expression of IL-1β and TNF-α showed significant differences between the two groups (P<0.05). Conclusions: Penetrating bone defects, inflammation, and a maxillary site are prognostic factors for a poor outcome after treatment of extensive radicular cysts. Endodontic microsurgery-microscopic apicoectomy is a new technique for treatment of an extensive radicular cyst, and this study is the first to identify factors that influence the outcome after extirpation of the cyst. 続きを見る
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