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Child-Pugh Classification using Magnetic Resonance Imaging using Gadoxetic Acid-based Contrast Agent Compared with Indocyanine Green and 99mTc-galactosyl-human Serum Albumin Liver Scintigraphy

フォーマット:
論文
責任表示:
Manduul, Enkhjargal ; Nakajima, Takahito ; Shibuya, Kei ; Shrestha, Suman ; Hirasawa, Hiromi ; Tsushima, Yoshito
言語:
英語
出版情報:
北関東医学会, 2019-08-01
著者名:
Manduul, Enkhjargal
Nakajima, Takahito
Shibuya, Kei
Shrestha, Suman
Hirasawa, Hiromi
Tsushima, Yoshito
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掲載情報:
The Kitakanto medical journal = 北関東医学
ISSN:
1343-2826  CiNii Research  JAIRO
巻:
69
通号:
3
開始ページ:
183
終了ページ:
189
バージョン:
VoR
概要:
Journal Article<br />This study evaluated liver function using gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) to improve assessment of patients with liver tumors compared to Child-Pugh classification (CPC). Materials and methods: The liver function of 59 patients was assessed to determine the indication for heavy ion therapy. Clinical and laboratory assessments, including 99mTc-GSA liver scintigraphy and indocyanine green … retention index (ICGR15), were performed for liver function assessment. EOB-MRI was performed on T1W1 images both before and after Gd-EOB-DTPA administration and hepatobiliary phase images were acquired 20-min post-injection. Liver parenchymal enhancement ratio (LER) was measured based on liver-to-spleen (L/Sp) ratios calculating the average liver intensity divided by spleen intensity. Results: The mean LER values on MRI were 138.2±12.8 (133.9-142.5), 115.7±11.6 (110.0-121.5), and 93.2±15.8 (73.6-112.9) in CPC-A, -B and -C, respectively. From the correlation between the LER on MRI and ICGR15 and parameters of 99mTc-GSA liver scintigraphy, LER on MRI was highly significantly correlated with ICGR15 (r=-0.67; p<0.0001). Discussion: This study demonstrated that LER values on EOB-MRI could classify liver function and had high correlation with CPC and ICGR15. 続きを見る
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