Der(2)t(2;11)(p21;q23), a Variant form of t(2;11), in Biphenotypic Acute Leukemia with T Lymphoid Lineage and M yeloid Lineage Differentiation

フォーマット:

論文

責任表示:

Miyazawa, Yuri ; Irisawa, Hiroyuki ; Matsushima, Takafumi ; Mitsui, Takeki ; Uchiumi, Hideki ; Saitoh, Takayuki ; Handa, Hiroshi ; Karasawa, Masamitsu ; Murakami, Hirokazu ; Tsukamoto, Norifumi ; Nojima, Yoshihisa

言語:

英語

出版情報:

北関東医学会, 2012-08-01

著者名:

Miyazawa, Yuri

Irisawa, Hiroyuki

Matsushima, Takafumi

Mitsui, Takeki

Uchiumi, Hideki

Saitoh, Takayuki

Handa, Hiroshi

Karasawa, Masamitsu

Murakami, Hirokazu

Tsukamoto, Norifumi

Nojima, Yoshihisa

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掲載情報:

The Kitakanto medical journal = 北関東医学

ISSN:

1343-2826    

巻:

62

通号:

3

開始ページ:

287

終了ページ:

290

バージョン:

VoR

概要:

Journal Article<br />We describe a patient with biphenotypic acute leukemia (BAL) with T-lymphoid lineage and\nmyeloid lineage differentiation［BAL (T/M)］. Cytogenetic analysis revealed complex chromosomal\nabnormalities, including der … (2)t(2;11)(p21;q23). Neither leukemia cells nor T-cell receptor gene\nrearrangements were detected in the bone marrow samples after four courses of high dose cytosine\narabinoside regimen. However, der(2)t(2;11)(p21;q23) anomaly persisted in most of metaphases.\nFluorescence in situ hybridization (FISH)analysis with a probe for MLL did not detect the split signal.\nForty-five cases of hematological disorder with t(2;11)(p21;q23) abnormality have been previously\nreported. The majority of such cases have been classified as myelodysplastic syndrome(MDS) or acute\nmyeloid leukemia (AML). This is the first case BAL (T/M) associated with a t(2;11)(p21;q23)\nanomaly. 続きを見る