Antineoplastic Effects of Interferon-Alpha and -Gamma in Metastatic Renal Cell Carcinoma Xenografts in Nude Mice

フォーマット:

論文

責任表示:

Ito, Yoshikazu Z. ; Hiromachi, Sachiko ; Shirahama, Akiko ; Arai, Michiko ; Futawatari, Tamae ; Nakazato, Yoichi a6fda3e0d86bb4578a02926de06c4502

言語:

英語

出版情報:

群馬大学医療技術短期大学部, 1994-03-31

著者名:

Ito, Yoshikazu Z.

Hiromachi, Sachiko

Shirahama, Akiko

Arai, Michiko

Futawatari, Tamae

Nakazato, Yoichi a6fda3e0d86bb4578a02926de06c4502

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掲載情報:

群馬大学医療技術短期大学部紀要

ISSN:

0389-7540    

巻:

14

開始ページ:

149

終了ページ:

157

バージョン:

VoR

概要:

application/pdf<br />Departmental Bulletin Paper<br />Combination treatment with human natural interferon-alpha (IFN-alpha) and natural interferon-gamma (IFN-gamma) markedly reduced the weight of metastatic human renal cell carcinoma (RCC) transplanted into nude mice. Monotherapy with IFN-alpha or IFN-gamma inhibited the tumor growth without reducing the tumor weight. After combination treatment with IFN-alpha and-gamma, histological … features showed notable reduction in the number of mitotic tumor cells and appreciable fibrosis in the stroma of the tumor. Infiltration of macrophages in the tumor was sparse. The results suggested that the antitumor activity of the IFNs is by direct cellular action. The general condition of tumor-bearing mice treated with IFN-alpha and-gamma was well retained, while marked emaciation was observed in the untreated tumor-bearing animals. The finding indicated that the combination treatment of RCC with IFN-alpha and-gamma may reduce the tumor burden of host mice. 続きを見る