Serum Apolipoprotein M Levels are Correlated with Biomarkers of Coagulation

フォーマット:

論文

責任表示:

Yoshida, Kensuke ; Kimura, Takao ; Shimizu, Tomo ; Sato, Koichi ; Aoki, Tomoyuki ; Sumino, Hiroyuki ; Tsunekawa, Katsuhiko ; Miyazaki, Osamu ; Fukamachi, Isamu ; Nakajima, Katsuyuki ; Okajima, Fumikazu ; Murakami, Masami

言語:

英語

出版情報:

北関東医学会, 2016-02-01

著者名:

Yoshida, Kensuke

Kimura, Takao

Shimizu, Tomo

Sato, Koichi

Aoki, Tomoyuki

Sumino, Hiroyuki

Tsunekawa, Katsuhiko

Miyazaki, Osamu

Fukamachi, Isamu

Nakajima, Katsuyuki

Okajima, Fumikazu

Murakami, Masami

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掲載情報:

The Kitakanto medical journal = 北関東医学

ISSN:

1343-2826      

巻:

66

通号:

1

開始ページ:

1

終了ページ:

6

バージョン:

VoR

概要:

Journal Article<br />Background:Apolipoprotein M (ApoM) is bound to high-density lipoprotein (HDL) in plasma, and HDL hasanticoagulation effects. However, the association between ApoM and biomarkers of coagulation was unclear.Therefor … e, we investigated relationships between ApoM and biomarkers of coagulation.Methods: Serum samples from 233 Japanese participants including with diabetes mellitus, hypertension,dyslipidemia, or healthy controls were analyzed. Serum ApoM levels were measured using Enzyme-LinkedImmuno-Sorbent Assay(ELISA).Results:Analysis of all 233 participants showed that ApoM levels were positively correlated with age (r＝0.284,p＜0.001), total cholesterol (TC;r＝0.477, p＜0.001), HDL-cholesterol (HDL-C;r＝0.234, p＜0.001) and lowdensitylipoprotein cholesterol (LDL-C;r＝0.331, p＜0.001). Higher ApoM levels were correlated with shorteractivated partial thromboplastin time(APTT;r＝－0.226,p＝0.001) and prothrombin time(PT,％;r＝0.326,p＜0.001). Separate analysis of the 115 healthy controls showed that ApoM levels were positively correlated with age,TC, HDL-C and LDL-C, and higher ApoM levels were correlated with shorter PT.Conclusion:Serum levels of ApoM may influence biomarkers of coagulation. 続きを見る