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論文
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Toyoizumi, Osamu ; Oriuchi, Noboru ; Miyakubo, Mitsuyuki ; Ishikita, Tomohiro ; Nakasone, Yoshiki ; Negishi, Akihide ; Endo, Keigo ; Nakajima, Takashi ; Mogi, Kenji ; Yokoo, Satoshi ; 豊泉, 修
概要:
Journal Article<br />第2回北関東医学会 The Kitakanto Medical Journal優秀論文賞
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論文
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Negishi, Akihide ; Mogi, Kenji ; Yamaguchi, Toru
概要:
application/pdf<br />Journal Article<br />Background & Aims: Some oral mucosal diseases display clear predispositions toward certain sites of\noccurrence. Oral lichen planus is one such disease, and is thought to have some relationships
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with cell-mediated immunity leading to a tendency to develop on the buccal mucosa. The aim of this study was\nto investigate the distribution of Langerhans cells in various sites of oral mucosa. Methods: Immunohistochemical\nexamination using an anti-S100 antibody was performed for 47 samples of healthy oral\nmucosa and skin. Results: S100-positive cells were more frequent in lining mucosa than in masticatory\nmucosa. Significantly more S100-positive cells were found in buccal mucosa than in other sites.\nConclusions: Langerhans cells are positive for S100 and are thought to represent antigen-presenting\ncells. These cells were most frequent in buccal mucosa, a result that is in accordance with the predisposition\nof oral lichen planus.
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