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論文
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Kurashige, Satonori ; Takashima, Tetsuo ; Mitsuhashi, Susumu
概要:
application/pdf<br />Departmental Bulletin Paper<br />We could make the experimental model of the ascending urinary tract infection of mice with Pseudomonas aeruginosa. Microorganisms were infected into bladder of mouse after
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surgical insertion of a small glass bead and urethra was ligated to stop urinary flow for two hours. A number of microorganisms was found in kidneys and bladders of all mice even 35 days after the infection. Histopathological studies indicated that characteristic pyelitis was induced in all mice by the method described in this paper.
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| 2.
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論文
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Kurashige, Satonori ; Yoshida, Toshiharu ; Akuzawa, Yuki ; Teshima, Chisato ; Mitsuhashi, Susumu
概要:
application/pdf<br />Departmental Bulletin Paper<br />We tried to use Boyden's chamber for assaying migration inhibition of human polymorphonuclear (PMN) leukocytes. The migration of human PMN leukocytes through a polycarbonate filter
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was retarded when human peripheral white blood cells (WBC) including sensitized lymphocytes were mixed with the corresponding antigen (PPD, chlorpromazine or cephalexin). By the contrast, the addition of the antigen did not inhibit the migration of PMN leukocytes when the WBC including nonsensitized lymphocytes were used for assay. These results suggest that we are able to assay in vitro delayed hypersensitivity by the migration inhibition test with Boyden's chamber. With our method, more quantitative results can be obtained in a shorter time than other methods.
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| 3.
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論文
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Kurashige, Satonori ; Yoshida, Toshiharu ; Mitsuhashi, Susumu
概要:
application/pdf<br />Departmental Bulletin Paper<br />In vitro immune responsiveness of Sarcoma 180-bearing mice was studied and following results were obtained. 1) Humoral and PHA responses were kept normal level for 4 weeks
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and retarded at 6 weeks (advanced stage) after tumor transplantation. 2) Cellular immune response against syngeneic tumor cells was enhanced in early stage (2 weeks) and supressed in advanced stage (6 weeks) of tumor-bearing state. 3) But regression of tumor was not observed in early stage since chemotactic activity of macrophages suppressed from early stage. 4) Purine nucleoside phosphorylase (PNP) activity of spleen lymphocytes increased in early stage (2 weeks) but decreased in advanced stage (6 weeks), suggesting that PNP activity changed in accordance with the cellular immune responsiveness against syngeneic tumor cells.
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