The Influence of Attenuation and Scatter Corrections on Quantitative Analysis of 123I-FP-CIT SPECT Brain Imaging

フォーマット:

論文

責任表示:

Kanzaki, Takao ; Tran, Vu Quynh Vy ; Higuchi, Tetsuya ; Nakajima, Takahito ; Achmad, Arifudin ; Takahashi, Yasuyuki ; Taketomi-Takahashi, Ayako ; Suto, Takayuki ; Tsushima, Yoshito

言語:

英語

出版情報:

北関東医学会, 2019-05-01

著者名:

Kanzaki, Takao

Tran, Vu Quynh Vy

Higuchi, Tetsuya

Nakajima, Takahito

Achmad, Arifudin

Takahashi, Yasuyuki

Taketomi-Takahashi, Ayako

Suto, Takayuki

Tsushima, Yoshito

続きを見る

掲載情報:

The Kitakanto medical journal = 北関東医学

ISSN:

1343-2826    

巻:

69

通号:

2

開始ページ:

121

終了ページ:

127

バージョン:

VoR

概要:

Journal Article<br />Objective: [123I] N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) or dopamine transporter (DAT) SPECT scan quantitatively depicts striatum dopamine transporter density. The specific binding ratio (SBR) is important for Parkinson's disease (PD) diagnosis. Correction techniques may improve 123I-FP-CIT image quality, but they are currently not standardized. … We aim to determine attenuation correction (AC) and scatter correction (SC) influence on 123I-FP-CIT quantitative analysis. Methods: We preformed SPECT imaging on a striatal phantom representing striatum-to-background ratios ranging from 10:1 to 1:1. We used the Chang method for AC and triple energy window for SC. Commercially available software semi-automatically calculated SBR. We performed correlation analysis between SBR and the actual concentration ratio in four groups: no correction (NC), SC, AC, and combined correction (CC), paying particular attention to SBR values below the clinical cut-off (4.5). We applied the same imaging conditions, reconstruction, and corrections on 49 human 123I-FP-CIT SPECT studies. Asymmetric index values (AI) were also analyzed. Receiver operating characteristic (ROC) analysis provided AI diagnostic cut-off values in PD patients. PD patient population whose AI values were above these cut-off value were subject to a correlation study to confirm the association between their clinical symptoms and 123I-FP-CIT SPECT. Results: Phantom study. AC or CC increased SBR 123I-FP-CIT SPECT, making them very close to the standard ratios (AC: y=1.19x - 0.7; R2=0.98; CC: y=1.4x - 1.2; R2=0.98), while NC and SC underestimated SBR at lower values (1 to 4). Clinical study. There was no difference in SBR between NC and SC, while AC and CC produced significantly higher SBR than NC (p<0.0001). Only SC affected AI values (p<0.05). The association between clinical symptoms and 123I-FP-CIT imaging results were maintained only when either NC (n=12, p<0.05) or CC (n=14, p<0.05) was applied. Conclusions: AC increased SBR more than other corrections, while SC increased AI value more than other corrections. The association between clinical symptom and SPECT findings were maintained when either NC or CC was applied. These correction methods should be carefully selected for 123I-FP-CIT SPECT brain imaging. 続きを見る