Stress-induced Biomarkers in Liver with Non-alcohol Fatty Liver Diseases and Non-alcohol Steatohepatitis

フォーマット:

論文

責任表示:

Ono, Hiromi ; Tanaka, Akira ; Nakazato, Kyoumi ; Hasegawa, Yutaka ; Kim, Ke Ih ; Kim, Soo Ryang ; Nakajima, Katsuyuki ; Nagamine, Takeaki

言語:

英語

出版情報:

北関東医学会, 2014-02-01

著者名:

Ono, Hiromi

Tanaka, Akira

Nakazato, Kyoumi

Hasegawa, Yutaka

Kim, Ke Ih

Kim, Soo Ryang

Nakajima, Katsuyuki

Nagamine, Takeaki

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掲載情報:

The Kitakanto medical journal = 北関東医学

ISSN:

1343-2826      

巻:

64

通号:

1

開始ページ:

13

終了ページ:

22

バージョン:

VoR

概要:

Journal Article<br />Background& Aims : A comparative study between plasma diagnostic markers and oxidative stressinduced biomarkers localized differently in the liver has not been reported in non-alcohol fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH). Methods : Pathological observations by Hematoxylin and Eosin (HE) staining and immunostaining by specific antibodies against metallothionein (MT)-1/2 and-3,heme oxygenase-1 … (HO-1), adiponectin using biopsy samples and plasma diagnostic makers were determined in 37 cases. Results : The MT-1/2,HO-1 and adiponectin levels were all significantly reduced in the liver with NASH compared with NAFLD and control. MT-1/2 was most strongly stained in hepatocytes in the normal and NAFLD liver,while it was significantly reduced in NASH. Adiponectin was stained significantly less at blood vessels in NASH compared with NAFLD and controls. HO-1 was also stained significantly less in the Kupffer cells in NASH compared with NAFLD and controls. MT-3 was stained similarly among the three groups at blood vessel cells. Those biomarkers trended negatively with plasma liver injury biomarkers. Conclusions : The significantly reduced expression of oxidative stress-induced biomarkers in NASH may be associated with the degree of pathological damage. In particular, MT-1/2 appears to exert an important effect in hepatocytes against stress-induced damage in NASH. 続きを見る