Antitumor Effect of Interleukin 2 and Cyclophosphamide Administration

フォーマット:

論文

責任表示:

Kurashige, Satonori ; Akuzawa, Yuki ; Kodama, Kazue

言語:

英語

出版情報:

群馬大学医療技術短期大学部, 1989-03-31

著者名:

• Kurashige, Satonori
• Akuzawa, Yuki
• Kodama, Kazue

掲載情報:

群馬大学医療技術短期大学部紀要

ISSN:

0389-7540    

巻:

9

開始ページ:

169

終了ページ:

179

バージョン:

VoR

概要:

application/pdf<br />Departmental Bulletin Paper<br />EL4-bearing C57BL mice were treated cyclophosphamide and/or with IL2. Mice treated with cyclophosphamide alone survived significantly longer than nontreated mice, while IL2-treated mice did not. Mice treated with both cyclophosphamide and IL2 survived significantly longer than mice treated with cyclophosphamide alone. IL2 response of lymphocytes was markedly depressed in EL4-bearing mice. Lymphocytes … from EL4-bearing mice treated with cyclophosphamide alone responded to IL2 significantly higher than those from mice treated with IL2 alone or those from nontreated mice. Lymphocytes from mice treated with both cyclophosphamide and IL2 responded to IL2 almost same as normal lymphocytes. Cyclophosphamide treatment protected the appearance of both suppressor factor that were found in EL4-bearing mice and inhibited IL2 response of lymphocytes. These results suggested that combination therapy of cyclophosphamide and IL2 showed synergistic antitumor effect through the protection of IL2 responsiveness from suppression by suppressors. 続きを見る